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BMS-262084

Chemical Structure : BMS-262084

CAS No.: 253174-92-4

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BMS-262084 (BMS262084)

Catalog No.: PC-25174Not For Human Use, Lab Use Only.

BMS-262084 is a potent and highly selective inhibitor of human tryptase with IC50 of 4 nM, >100-fold selective over Plasmin, Thrombin, uPA and tPA, also is an irreversible inhibitor of factor Xia with IC50 of 2.8 nM, shows antithrombotic effects.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-262084 is a potent and highly selective inhibitor of human tryptase with IC50 of 4 nM, >100-fold selective over Plasmin, Thrombin, uPA and tPA, also is an irreversible inhibitor of factor XIa with IC50 of 2.8 nM, shows antithrombotic effects.

Physicochemical Properties

M.Wt 425.49
Formula C18H31N7O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,3R)-1-(4-(tert-butylcarbamoyl)piperazine-1-carbonyl)-3-(3-((diaminomethylene)amino)propyl)-4-oxoazetidine-2-carboxylic acid

References

1. Slusarchyk WA, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8.

2. Schumacher WA, et al. Eur J Pharmacol. 2007 Sep 10;570(1-3):167-74.

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