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BMS-345541 hydrochloride

Chemical Structure : BMS-345541 hydrochloride

CAS No.: 547757-23-3

BMS-345541 hydrochloride (BMS345541 hydrochloride)

Catalog No.: PC-42631Not For Human Use, Lab Use Only.

BMS-345541 hydrochloride is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-345541 hydrochloride is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM.
BMS-345541 is less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε.
BMS-345541 inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM.
BMS-345541 has excellent pharmacokinetics in mice.

Physicochemical Properties

M.Wt 291.7792
Formula C14H18ClN5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-, hydrochloride (1:1)

References

1. Burke JR, et al. J Biol Chem. 2003 Jan 17;278(3):1450-6.

2. McIntyre KW, et al. Arthritis Rheum. 2003 Sep;48(9):2652-9.

3. López-Guerra M, et al. Clin Cancer Res. 2009 Apr 15;15(8):2767-76.

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