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Chemical Structure : BMS-351
Catalog No.: PC-49296Not For Human Use, Lab Use Only.
BMS-351 (BMS351) is a potent, selective, reversible, nonsteroidal CYP17A1 lyase inhibitor with IC50 of 19 nM.
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BMS-351 (BMS351) is a potent, selective, reversible, nonsteroidal CYP17A1 lyase inhibitor with IC50 of 19 nM.
BMS-351 displays hydroxylase/lyase ratio value of 10, and good selectivity over CYPs 11B1 and 21A2 in human and cyno (IC50>7500 nM).
BMS-351 (1.5 mg/kg, BID) treatment led a remarkable reduction in testosterone levels with minimal glucocorticoid and mineralcorticoid perturbation in castrated cynomolgus monkeys, compared to abiraterone.
| M.Wt | 291.277 | |
| Formula | C15H12F3N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Audris Huang, et al. ACS Med Chem Lett. 2015 Dec 2;7(1):40-5.
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