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BMS-351

Chemical Structure : BMS-351

CAS No.: 1370001-71-0

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BMS-351 (BMS351)

Catalog No.: PC-49296Not For Human Use, Lab Use Only.

BMS-351 (BMS351) is a potent, selective, reversible, nonsteroidal CYP17A1 lyase inhibitor with IC50 of 19 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-351 (BMS351) is a potent, selective, reversible, nonsteroidal CYP17A1 lyase inhibitor with IC50 of 19 nM.
    BMS-351 displays hydroxylase/lyase ratio value of 10, and good selectivity over CYPs 11B1 and 21A2 in human and cyno (IC50>7500 nM).
    BMS-351 (1.5 mg/kg, BID) treatment led a remarkable reduction in testosterone levels with minimal glucocorticoid and mineralcorticoid perturbation in castrated cynomolgus monkeys, compared to abiraterone.

    Physicochemical Properties

    M.Wt 291.277
    Formula C15H12F3N3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-methylpyridin-3-yl)-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazole

    References

    1. Audris Huang, et al. ACS Med Chem Lett. 2015 Dec 2;7(1):40-5.

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