Catalog No.: PC-36150Not For Human Use, Lab Use Only.
BMS-466442 (BMS466442) is small molecule inhibitor of the Alanine-Serine-Cysteine-1 transporter (ASC-1, SLC7A10), selectively inhibits ASC-1 mediated D-serine uptake in human asc-1 expressing cells and primary cultures with IC50 of 36.8 and 19.7 nM, respectively.
BMS-466442 (BMS466442) is small molecule inhibitor of the Alanine-Serine-Cysteine-1 transporter (ASC-1, SLC7A10), selectively inhibits ASC-1 mediated D-serine uptake in human asc-1 expressing cells and primary cultures with IC50 of 36.8 and 19.7 nM, respectively.
BMS-466442 inhibited ASC-1 but was not a competitive substrate for this transporter.
BMS-466442 is the first reported selective inhibitor of the ASC-1 transporter.
