Chemical Structure : BMS-466442
CAS No.:
1598424-76-0
BMS-466442
(BMS466442;BMS 466442)
Catalog No.: PC-36150Not For Human Use, Lab Use Only.
BMS-466442 (BMS466442) is small molecule inhibitor of the Alanine-Serine-Cysteine-1 Transporter (ASC-1, SLC7A10), selectively inhibits asc-1 mediated D-serine uptake in human asc-1 expressing cells and primary cultures with IC50 of 36.8 and 19.7 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BMS-466442 (BMS466442) is small molecule inhibitor of the Alanine-Serine-Cysteine-1 Transporter (ASC-1, SLC7A10), selectively inhibits asc-1 mediated D-serine uptake in human asc-1 expressing cells and primary cultures with IC50 of 36.8 and 19.7 nM, respectively; BMS-466442 inhibited asc-1 but was not a competitive substrate for this transporter, BMS-466442 is the first reported selective inhibitor of the asc-1 transporter.
Physicochemical Properties
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M.Wt
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524.577
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Formula
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C30H28N4O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl (S)-2-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)acetate
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References
1. Brown JM, et al. J Neurochem. 2014 Apr;129(2):275-83.
2. Torrecillas IR, et al. ACS Chem Neurosci. 2019 Mar 14. doi: 10.1021/acschemneuro.9b00019.
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