BMS-5 |CAS:1338247-35-0 Probechem Biochemicals

Chemical Structure : BMS-5

CAS No.: 1338247-35-0

BMS-5 (LIMKi-3)

Catalog No.: PC-45451Not For Human Use, Lab Use Only.

BMS-5 (LIMKi-3) is a cell-permeable, potent, selective inhibitor of LIMK with IC50 of 7/8 nM for LIMK1/2, respectively.

Packing	Price	Stock
25 mg	$198	In stock
50 mg	$328	In stock
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Biological Activity

BMS-5 (LIMKi-3) is a cell-permeable, potent, selective inhibitor of LIMK with IC50 of 7/8 nM for LIMK1/2, respectively.
BMS-5 (LIMKi-3) effectively destabilizes F-actin structure in MDA-MB-231 breast cancer cells (3-10 uM) with concomitant blockage of invasion (by 93% at 10 uM).
BMS-5 (LIMKi-3) significantly affects porcine oocyte maturation, causes aberrant actin distribution and spindle positioning.

Physicochemical Properties

M.Wt	431.2871
Formula	C17H14Cl2F2N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-

References

1. Ross-Macdonald P, et al. Mol Cancer Ther. 2008 Nov;7(11):3490-8.

2. Sparrow N, et al. J Neurosci. 2012 Apr 11;32(15):5284-97.

3. Jia RX, et al. PeerJ. 2016 Oct 12;4:e2553. eCollection 2016.

BMS-5 (LIMKi-3)

Biological Activity

Physicochemical Properties

References

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