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Chemical Structure : BMS-5
CAS No.: 1338247-35-0
Catalog No.: PC-45451Not For Human Use, Lab Use Only.
BMS-5 (LIMKi-3) is a cell-permeable, potent, selective inhibitor of LIMK with IC50 of 7/8 nM for LIMK1/2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BMS-5 (LIMKi-3) is a cell-permeable, potent, selective inhibitor of LIMK with IC50 of 7/8 nM for LIMK1/2, respectively.
BMS-5 (LIMKi-3) effectively destabilizes F-actin structure in MDA-MB-231 breast cancer cells (3-10 uM) with concomitant blockage of invasion (by 93% at 10 uM).
BMS-5 (LIMKi-3) significantly affects porcine oocyte maturation, causes aberrant actin distribution and spindle positioning.
| M.Wt | 431.2871 | |
| Formula | C17H14Cl2F2N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl- |
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1. Ross-Macdonald P, et al. Mol Cancer Ther. 2008 Nov;7(11):3490-8.
2. Sparrow N, et al. J Neurosci. 2012 Apr 11;32(15):5284-97.
3. Jia RX, et al. PeerJ. 2016 Oct 12;4:e2553. eCollection 2016.
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