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BMS-687453

Chemical Structure : BMS-687453

CAS No.: 1000998-59-3

BMS-687453 (BMS687453, BMS 687453)

Catalog No.: PC-42693Not For Human Use, Lab Use Only.

BMS-687453 (BMS687453) is a potent and selective PPARα agonist with EC50 of 10 nM for human PPARα and 410-fold selectivity over human PPARγ in PPAR-GAL4 transactivation assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-687453 (BMS687453) is a potent and selective PPARα agonist with EC50 of 10 nM for human PPARα and 410-fold selectivity over human PPARγ in PPAR-GAL4 transactivation assays.
BMS-687453 has negligible cross-reactivity against a panel of human nuclear hormone receptors including PPARδ.
BMS-687453 demonstrates an excellent pharmacological and safety profile for the treatment of atherosclerosis and dyslipidemia.

Physicochemical Properties

M.Wt 444.8649
Formula C22H21ClN2O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-

References

1. Li J, et al. J Med Chem. 2010 Apr 8;53(7):2854-64.

2. Mukherjee R, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26.

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