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Chemical Structure : BMS-687453
CAS No.: 1000998-59-3
Catalog No.: PC-42693Not For Human Use, Lab Use Only.
A potent and selective PPARα agonist with EC50 of 10 nM for human PPARα and 410-fold selectivity over human PPARγ in PPAR-GAL4 transactivation assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $144 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $480 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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A potent and selective PPARα agonist with EC50 of 10 nM for human PPARα and 410-fold selectivity over human PPARγ in PPAR-GAL4 transactivation assays; has negligible cross-reactivity against a panel of human nuclear hormone receptors including PPARδ; demonstrates an excellent pharmacological and safety profile for the treatment of atherosclerosis and dyslipidemia.
Dyslipidemia
Preclinical
| M.Wt | 444.8649 | |
| Formula | C22H21ClN2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)- |
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1. Li J, et al. J Med Chem. 2010 Apr 8;53(7):2854-64.
2. Mukherjee R, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26.
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