Catalog No.: PC-61068Not For Human Use, Lab Use Only.
BMS-711939 (BMS711939) is a potent and selective human PPARα agonist with EC50 of 4 nM, >1,000-fold selectivity over human PPARγ (EC50=4.5 uM) and PPARδ (EC50 >100 uM) in PPAR-GAL4 transactivation assays.
BMS-711939 (BMS711939) is a potent and selective human PPARα agonist with EC50 of 4 nM, >1,000-fold selectivity over human PPARγ (EC50=4.5 uM) and PPARδ (EC50 >100 uM) in PPAR-GAL4 transactivation assays.
BMS-711939 shows much lower potency against mouse PPARα than human PPARα.
BMS-711939 robustly increases apolipoprotein (Apo) A1 and high-density lipoprotein cholesterol in human ApoA1 transgenic mice and lower low-density lipoprotein-cholesterol and triglycerides in fat-fed hamsters.
BMS-711939 also prevents the LXR agonist-induced elevation of serum triglycerides.
