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Chemical Structure : BMS-711939
Catalog No.: PC-61068Not For Human Use, Lab Use Only.
BMS-711939 (BMS711939) is a potent and selective human PPARα agonist with EC50 of 4 nM, >1,000-fold selectivity over human PPARγ (EC50=4.5 uM) and PPARδ (EC50 >100 uM) in PPAR-GAL4 transactivation assays.
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BMS-711939 (BMS711939) is a potent and selective human PPARα agonist with EC50 of 4 nM, >1,000-fold selectivity over human PPARγ (EC50=4.5 uM) and PPARδ (EC50 >100 uM) in PPAR-GAL4 transactivation assays.
BMS-711939 shows much lower potency against mouse PPARα than human PPARα.
BMS-711939 robustly increases apolipoprotein (Apo) A1 and high-density lipoprotein cholesterol in human ApoA1 transgenic mice and lower low-density lipoprotein-cholesterol and triglycerides in fat-fed hamsters.
BMS-711939 also prevents the LXR agonist-induced elevation of serum triglycerides.
| M.Wt | 462.858 | |
| Formula | C22H20ClFN2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shi Y, et al. ACS Med Chem Lett. 2016 Apr 4;7(6):590-4.
2. Mukherjee R, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26.
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