BMS-737 | CYP17 lyase inhibitor | Probechem Biochemicals

Chemical Structure : BMS-737

BMS-737 (BMS737)

Catalog No.: PC-49301Not For Human Use, Lab Use Only.

BMS-737 (BMS737) is a potent, , selective, non-steroidal, reversible inhibitor of CYP17 lyase, 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase.

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Biological Activity

BMS-737 (BMS737) is a potent, , selective, non-steroidal, reversible inhibitor of CYP17 lyase, 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase.
BMS-737 demonstrates a robust 83% lowering of testosterone without any significant perturbation of the mineralocorticoid and glucocorticoid levels in cynomologous monkeys in a 1-day PK/PD study.

Physicochemical Properties

M.Wt	306.304
Formula	C16H11FN6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)pyrimidin-4-amine

References

1. Padmakar Darne C, et al. Bioorg Med Chem Lett. 2022 Aug 27;75:128951.

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BMS-737 (BMS737)

Biological Activity

Physicochemical Properties

References

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