BMS-754807 (BMS754807) is a potent, reversible, orally active inhibitor of IGF-1R/Insulin receptor with IC50 of 1.8 and 1.7 nM, respectively.
BMS-754807 shows additional off-target activities Met, RON, TrkA, TrkB, AurA, and AurB (IC50=5-45 nM) in a panel of 27 kinases.
BMS-754807 inhibits the growth of a broad range of human tumor types in vitro (IC50=5-365 nM), induces PARP and Caspase 3 cleavage, promotes apoptosis.
BMS-754807 exhibits tumor growth inhibition in xenograft tumor models.
