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Chemical Structure : BMS-754807
CAS No.: 1001350-96-4
Catalog No.: PC-42444Not For Human Use, Lab Use Only.
BMS-754807 (BMS 754807, BMS754807) is a potent, reversible, orally active inhibitor of IGF-1R/Insulin receptor with IC50 of 1.8 and 1.7 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $28 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote |
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BMS-754807 (BMS754807) is a potent, reversible, orally active inhibitor of IGF-1R/Insulin receptor with IC50 of 1.8 and 1.7 nM, respectively.
BMS-754807 shows additional off-target activities Met, RON, TrkA, TrkB, AurA, and AurB (IC50=5-45 nM) in a panel of 27 kinases.
BMS-754807 inhibits the growth of a broad range of human tumor types in vitro (IC50=5-365 nM), induces PARP and Caspase 3 cleavage, promotes apoptosis.
BMS-754807 exhibits tumor growth inhibition in xenograft tumor models.
| M.Wt | 461.4948 | |
| Formula | C23H24FN9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrrolidinecarboxamide, 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoro-3-pyridinyl)-2-methyl-, (2S)- |
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1. Wittman MD, et al. Mol Cancer Ther. 2009 Dec;8(12):3341-9.
2. Carboni JM, et al. Mol Cancer Ther. 2009 Dec;8(12):3341-9.
3. Dinchuk JE, et al. Endocrinology. 2010 Sep;151(9):4123-32.
4. Huang F, et al. Cancer Res. 2010 Sep 15;70(18):7221-31.
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