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BMS-813160

Chemical Structure : BMS-813160

CAS No.: 1286279-29-5

BMS-813160 (BMS813160)

Catalog No.: PC-72668Not For Human Use, Lab Use Only.

BMS-813160 (BMS 813160) a potent and selective CCR2/5 dual antagonist with binding IC50 of 6.2/3.6 nM, respectively.

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10 mg $218 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-813160 (BMS 813160) a potent and selective CCR2/5 dual antagonist with binding IC50 of 6.2/3.6 nM, respectively.
BMS-813160 had excellent oral bioavailability and exhibited low clearance in dog and cyno.
BMS-813160 inhibited the migration of inflammatory monocytes and macrophages in the mouse thioglycollate-induced peritonitis model.

Physicochemical Properties

M.Wt 484.649
Formula C25H40N8O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-((1R,2S,5R)-2-((S)-3-((7-(tert-butyl)pyrazolo[1,5-a][1,3,5]triazin-4-yl)amino)-2-oxopyrrolidin-1-yl)-5-(tert-butylamino)cyclohexyl)acetamide

References

1. Cherney RJ, et al. ACS Med Chem Lett. 2021 Oct 15;12(11):1753-1758.

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