BMS-905 | TLR7/8 inhibitor | Probechem Biochemicals

Chemical Structure : BMS-905

CAS No.: 2205846-49-5

BMS-905 (BMS905)

Catalog No.: PC-38500Not For Human Use, Lab Use Only.

BMS-905 is a potent dual inhibitor of TLR7 and TLR8 with IC50 of 0.3 nM (TLR7, IL-6 inhibition in mouse blood), shows good selectivity against TLR9 and other TLR family members.

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Biological Activity

BMS-905 is a potent dual inhibitor of TLR7 and TLR8 with IC50 of 0.3 nM (TLR7, IL-6 inhibition in mouse blood), shows good selectivity against TLR9 and other TLR family members.

Physicochemical Properties

M.Wt	347.506
Formula	C23H29N3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole

References

1. Ratna Kumar Sreekantha, et al. ACS Medicinal Chemistry Letters. DOI: 10.1021/acsmedchemlett.2c00049

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BMS-905 (BMS905)

Biological Activity

Physicochemical Properties

References

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