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BMS-911543

Chemical Structure : BMS-911543

CAS No.: 1271022-90-2

BMS-911543 (BMS911543;BMS 911543)

Catalog No.: PC-44289Not For Human Use, Lab Use Only.

BMS-911543 is a potent and selective small-molecule inhibitor of JAK2 with IC50 of 1.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-911543 is a potent and selective small-molecule inhibitor of JAK2 with IC50 of 1.1 nM.
BMS-911543 displays 350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively.
BMS-911543 displays anti-proliferative effect on JAK2(V617F) MPNs and inhibits pSTAT5 in Ba/FJAK2V617F cells (IC50=60 nM).
BMS-911543 is highly active in in vivo models and orally bioactive.

Physicochemical Properties

M.Wt 432.5214
Formula C23H28N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide,N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-

References

1. Purandare AV, et al. Leukemia. 2012 Feb;26(2):280-8.

2. Wan H, et al. ACS Med Chem Lett. 2015 Jul 12;6(8):850-5.

3. Mace TA, et al. Oncotarget. 2015 Dec 29;6(42):44509-22.

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