Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Diglyceride Acyltransferase (DGAT)-BMS-963272
BMS-963272

Chemical Structure : BMS-963272

CAS No.: 1441057-15-3

Add to Favorites

BMS-963272 (BMS 963272)

Catalog No.: PC-73223Not For Human Use, Lab Use Only.

BMS-963272 is a potent, selective MGAT2 inhibitor with IC50 of 7.1 and 18 nM for human and mouse MAGT2, respectively.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-963272 is a potent, selective MGAT2 inhibitor with IC50 of 7.1 and 18 nM for human and mouse MAGT2, respectively.
    BMS-963272 decreaseed inflammation and fibrosis in CDAHFD and STAM, two murine nonalcoholic steatohepatitis (NASH) models.
    BMS-963272 did not cause diarrhea in high-fat-diet-treated cynomolgus monkeys, in contrast to a selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor.

    Physicochemical Properties

    M.Wt 525.45
    Formula C24H21F6N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2(1H)-Pyridinone, 5,6-dihydro-4-(4-methylphenyl)-3-(2H-tetrazol-5-yl)-6-[4-(4,4,4-trifluorobutoxy)phenyl]-6-(trifluoromethyl)-, (6S)-

    References

    1. Cheng D, et al. Cell Metab. 2022 Nov 1;34(11):1732-1748.e5.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: