Catalog No.: PC-38350Not For Human Use, Lab Use Only.
BMS-986251 is a potent, selective, orally active RORγt inverse agonist with EC50 of 12 nM in GAL-4 reporter assay in Jurkat cell line, and 24 nM in IL-17 human whole blood assay.
BMS-986251 is a potent, selective, orally active RORγt inverse agonist with EC50 of 12 nM in GAL-4 reporter assay in Jurkat cell line, and 24 nM in IL-17 human whole blood assay.
BMS-986251 displays high selectivity over ROR family members (RORα and RORβ) and other nuclear receptors (PXR, LXRα, and LXRβ) with IC50 >5,000 nM.
BMS-986251 inhibits IL-17F production in IL-2/IL-23 stimulated mouse pharmacodynamic (PD) model.
BMS-986251 reduces ear thickness in mouse acanthosis model, 15 mg/kg dose of BMS-986251 is comparable to the human anti-IL-23.
