| Cat. No. |
Product Name |
Information |
| PC-20040 |
IMU-935
RORγt inverse agonist
|
IMU-935 (Izumerogant, IMU935, IM105935) is a potent, selective and orally available inverse agonist of retinoic acid-related orphan receptor gamma (RORγt) with IC50 of 24 nM. |
| PC-49023 |
BMS-336
RORγt inhibitor
|
BMS-336 is a potent, selective, orally active RORγt (RORC2) inverse agonist with EC50 of 39 nM in RORγt reporter assays. |
| PC-38747 |
PCCR-1
RORγ inhibitor
|
PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR. |
| PC-38349 |
Cedirogant
RORγt inverse agonist
|
ABBV-157 (Cedirogant) is a small molecule inhibitor (inverse agonist) of RORγT being investigated for the treatment of immune-mediated diseases (e.g. Psoriasis). |
| PC-73062 |
A-9758
RORγt inhibitor
|
A-9758 (A9758) is a selective, small molecule inverse agonist of retinoid-related orphan receptor gamma t (hRORγt IC50=38 nM). |
| PC-35828 |
S18-000003
RORγt inhibitor
|
S18-000003 (S18-000003) is a potent, selective, orally bioavailable RORγt inhibitor with IC50 of 29 nM (hRORγt, GAL4), shows no significant activity against RORα, RORβ and LXRα/β(IC50>10 uM). |
| PC-35596 |
PF-06747711
RORγt inverse agonist
|
PF-06747711 (PF06747711) is a potent, selective, orally bioavailable RORC2 (RORγt) inverse agonist with IC50 of 4.1 nM. |
| PC-35557 |
GNE-6468
RORγ inverse agonist
|
GNE-6468 (GNE6468) is a potent and selective RORc (RORγ) inverse agonist (EC50=2 nM) with >1,000-fold selectivity for RORc over PPARγ. |
| PC-35413 |
RORγt inverse agonist 22
RORγt inverse agonist
|
RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ. |
| PC-35406 |
MRL-871
RORγt inhibitor
|
MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM. |
| PC-35405 |
SR2211
RORγt inhibitor
|
SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells. |
| PC-35306 |
CD12681
RORγ inverse agonist
|
CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR). |
