| Cat. No. |
Product Name |
Information |
| PC-35828 |
S18-000003
RORγt inhibitor
|
S18-000003 (S18-000003) is a potent, selective, orally bioavailable RORγt inhibitor with IC50 of 29 nM (hRORγt, GAL4), shows no significant activity against RORα, RORβ and LXRα/β(IC50>10 uM). |
| PC-35596 |
PF-06747711
RORγt inverse agonist
|
PF-06747711 (PF06747711) is a potent, selective, orally bioavailable RORC2 (RORγt) inverse agonist with IC50 of 4.1 nM. |
| PC-35570 |
RORγt inverse agonist 32
RORγt inverse agonist
|
RORγt inverse agonist 32 is a potent, orally bioavailable inverse agonist of RORγt with IC50 of 9 nM in SPA binding assays. |
| PC-35557 |
GNE-6468
RORγ inverse agonist
|
GNE-6468 (GNE6468) is a potent and selective RORc (RORγ) inverse agonist (EC50=2 nM) with >1,000-fold selectivity for RORc over PPARγ. |
| PC-35413 |
RORγt inverse agonist 22
RORγt inverse agonist
|
RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ. |
| PC-35406 |
MRL-871
RORγt inhibitor
|
MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM. |
| PC-35405 |
SR2211
RORγt inhibitor
|
SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells. |
| PC-35306 |
CD12681
RORγ inverse agonist
|
CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR). |
| PC-35085 |
SR1555 hydrochloride
RORγ inverse agonist
|
SR1555 hydrochloride is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells. |
| PC-35084 |
SR1555
RORγ inverse agonist
|
SR1555 is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells. |
| PC-43525 |
SR1001
RORα/RORγt agonist
|
SR1001 is a higly potent, specific, inverse agonist of both RORα and RORγt with binding Ki of 172 and 111 nM, does not binds RORβ and devoid of LXR activity. |
| PC-63532 |
LYC-55716
RORγ agonist
|
Cintirorgon (LYC-55716) is a potent, selective, and orally bioavailable Retinoic acid Receptor-related orphan receptor-γ (RORγ) agonist with FRET EC50 of 13 nM. |
