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PF-06747711

Chemical Structure : PF-06747711

CAS No.: 1892576-58-7

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PF-06747711 (PF06747711)

Catalog No.: PC-35596Not For Human Use, Lab Use Only.

PF-06747711 (PF06747711) is a potent, selective, orally bioavailable RORC2 (RORγt) inverse agonist with IC50 of 4.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-06747711 (PF06747711) is a potent, selective, orally bioavailable RORC2 (RORγt) inverse agonist with IC50 of 4.1 nM.
PF-06747711 inhibits IL-17A production by human Th17 cells with IC50 of 9.5 nM.
PF-06747711 reduce levels of IL-17A in vivo after oral dosing in mice and corresponding reduction in skin inflammation.

Physicochemical Properties

M.Wt 497.522
Formula C26H26F3N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide

References

1. Schnute ME, et al. J Med Chem. 2018 Aug 21. doi: 10.1021/acs.jmedchem.8b00392.

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