MRL-871 |CAS:1392809-08-3 Probechem Biochemicals

Chemical Structure : MRL-871

MRL-871 (MRL871)

Catalog No.: PC-35406Not For Human Use, Lab Use Only.

MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM.

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Biological Activity

MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM.
MRL-871 significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM.

Physicochemical Properties

M.Wt	444.794
Formula	C22H12ClF3N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid

References

1. Scheepstra M, et al. Nat Commun. 2015 Dec 7;6:8833.

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MRL-871 (MRL871)

Biological Activity

Physicochemical Properties

References

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