Catalog No.: PC-35413Not For Human Use, Lab Use Only.
RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ.
RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ.
RORγt inverse agonist 22 exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors。
RORγt inverse agonist 22 demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration.
