Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JNJ-61803534
CAS No.: 1917306-14-9
Catalog No.: PC-72400Not For Human Use, Lab Use Only.
JNJ-61803534 (JNJ 61803534) is a novel, selective and potent RORγt inverse agonist, inhibits RORγt-driven transcription with IC50 of 9.6 nM in 1-hybrid reporter assays.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JNJ-61803534 (JNJ 61803534) is a novel, selective and potent RORγt inverse agonist, inhibits RORγt-driven transcription with IC50 of 9.6 nM in 1-hybrid reporter assays.
JNJ-61803534 demonstrated high selectivity for RORγt over RORα and RORβ (IC50>2 uM), as well as against 18 human nuclear receptors and a panel of 52 receptors, ion channels and transporters, 28 GPCRs.
JNJ-61803534 dose-dependently suppressed production of IL-17A, IL-17F and IL-22 with IC50 values of 19nM, 22 nM and 27 nM, respectively, in human CD4+ T cells under Th17 differentiation, does not impair human nTreg suppressive function.
JNJ-61803534 specifically blocked RORγt-dependent pathways in cellular assays and significantly reduced inflammation in preclinical models.
| M.Wt | 622.404 | |
| Formula | C23H23Cl2F6N3O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Thiazolecarboxamide, 5-[2,3-dichloro-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[[(2R)-2-methyl-1-pyrrolidinyl]carbonyl]- |
|
1. Xiaohua Xue, et al. Sci Rep. 2021 May 26;11(1):11066.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
