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JTE-151

Chemical Structure : JTE-151

CAS No.: 1608139-41-8

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JTE-151 (JTE151)

Catalog No.: PC-20043Not For Human Use, Lab Use Only.

JTE-151 (JTE151) is a potent selective RORγ antagonist with EC50 of 14 nM, acts by suppressing overactive immune response through inhibition of RORγ related to the activation of Th17 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JTE-151 (JTE151) is a potent selective RORγ antagonist with EC50 of 14 nM, acts by suppressing overactive immune response through inhibition of RORγ related to the activation of Th17 cells.

    Physicochemical Properties

    M.Wt 499.99
    Formula C26H30ClN3O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-6-((2-chloro-4-methylphenyl)amino)-4-(4'-cyclopropyl-5-isobutyl-[3,5'-biisoxazol]-3'-yl)-6-oxohexanoic acid

    References

    1. Masayuki Kotoku, et al. J Med Chem. 2019 Mar 14;62(5):2837-2842.

    2. Nadim S Shaikh, et al. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2208-2217.

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