Catalog No.: PC-38747Not For Human Use, Lab Use Only.
PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR.
PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR.
PCCR-1 demonstrates promising potency for IL-17A inhibition in human and canine PBMCs and mouse splenocytes with no significant impact on Th1 and Th2 cytokines.
PCCR-1 exhibits significant efficacy in the acute CS model with dose-dependent inhibition of the PD biomarkers, effectively inhibited IL-17A release in whole blood and BALf samples from COPD patients.
