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BMS-986313

Chemical Structure : BMS-986313

CAS No.: 2226319-10-2

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BMS-986313 (BMS 986313)

Catalog No.: PC-38351Not For Human Use, Lab Use Only.

BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay.
    BMS-986313 demonstrated robust efficacy in preclinical models of psoriasis (the IMQ-induced skin lesion model and the IL-23-induced acanthosis model).

    Physicochemical Properties

    M.Wt 599.536
    Formula C26H25F8NO4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((3R,3aS,9bS)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-cyclopenta[a]naphthalen-3-yl)-2-hydroxy-2-methylpropanamide

    References

    1. Yang MG, et al. J Med Chem. 2021 Mar 11;64(5):2714-2724.

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