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Chemical Structure : BMS-986318
Catalog No.: PC-20976Not For Human Use, Lab Use Only.
BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays.
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BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays.
BMS-986318 exhibits EC50 of 350 nM in FXR steroid receptor coactivator 1 (SRC-1) recruitment assays.
BMS-986318 (10, 30, and 100 mg/kg) demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.
| M.Wt | 615.43 | |
| Formula | C30H23Cl2F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carpenter J, et al. ACS Med Chem Lett. 2021 Aug 5;12(9):1413-1420.
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