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BMS-986339

Chemical Structure : BMS-986339

CAS No.: 2477873-64-4

BMS-986339 (BMS986339)

Catalog No.: PC-47028Not For Human Use, Lab Use Only.

BMS-986339 is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 34 nM (hFXR-Gal4), demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-986339 is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 34 nM (hFXR-Gal4), demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo.

    Physicochemical Properties

    M.Wt 643.724
    Formula C35H41F4N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (1s,3s)-N-((4-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-hydroxy-N-(4'-(2-hydroxypropan-2-yl)-[1,1'-biphenyl]-3-yl)-3-(trifluoromethyl)cyclobutane-1-carboxamide

    References

    1. Susheel J Nara, et al. J Med Chem. 2022 Jun 15. doi: 10.1021/acs.jmedchem.2c00165.

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