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Chemical Structure : BMS-P5
CAS No.: 1550371-22-6
Catalog No.: PC-38089Not For Human Use, Lab Use Only.
BMS-P5 is a potent, specific inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 98 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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BMS-P5 is a potent, specific inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 98 nM.
BMS-P5 is selective for PAD4 over PAD1, -2, and -3 (IC50s >10 uM).
BMS-P5 inhibits PAD4 and prevents mouse myeloma-induced NET formation, prevents NETosis induced by human myeloma cells.
BMS-P5 significantly reduces plasma levels of cell-free DNA, exhibits anti-tumor effect in a syngeneic mouse model of multiple myeloma.
| M.Wt | 472.593 | |
| Formula | C27H32N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
((2S,5R)-5-amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone |
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1. Marina Li, et al. Mol Cancer Ther. 2020 Jul;19(7):1530-1538.
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