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BN82002

Chemical Structure : BN82002

CAS No.: 396073-89-5

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BN82002 (BN-82002;BN 82002)

Catalog No.: PC-60249Not For Human Use, Lab Use Only.

BN82002 is a potent Cdc25 dual specificity phosphatase inhibitor with IC50 of 2-6 uM for Cdc25A/B/C.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BN82002 is a potent Cdc25 dual specificity phosphatase inhibitor with IC50 of 2-6 uM for Cdc25A/B/C.
    BN82002 impairs the proliferation of tumoral cell lines and increases CDK1 inhibitory tyrosine phosphorylation, delays cell cycle progression in HeLa cells;.
    BN82002 reduces growth rate of human tumor xenografts in mice.

    Physicochemical Properties

    M.Wt 359.426
    Formula C19H25N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(dimethylamino)-2-methoxy-6-((methyl(4-nitrophenethyl)amino)methyl)phenol

    References

    1. Brezak MC, et al. Cancer Res. 2004 May 1;64(9):3320-5.

    2. Contour-Galcéra MO, et al. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12.

    3. Brenner AK, et al. Molecules. 2017 Mar 11;22(3). pii: E446.

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