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Chemical Structure : BNZ132-1
Catalog No.: PC-38316Not For Human Use, Lab Use Only.
BNZ132-1 (QITISILSQINRVFHEKFI) is a specific peptide inhibitor for the IL-2/IL-15 subfamily, directly binds to the γc molecule (CD132).
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BNZ132-1 (QITISILSQINRVFHEKFI) is a specific peptide inhibitor for the IL-2/IL-15 subfamily, directly binds to the γc molecule (CD132); BNZ132-1 shows no inhibition on non-γc-cytokines. BNZ132-1 inhibits γc-cytokines using murine PT-18 cells, but not IL-4/7/21. BNZ132-1 inhibits IL-2 and -15 with IC50 of 50-500 nM in human cells (NK92 cell line and ex vivo human T cells).
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1. Toshie Nata, et al. J Biol Chem. 2015 Sep 11;290(37):22338-51.
2. T Tiffany Wang, et al. Leukemia. 2019 May;33(5):1243-1255.
3. Raya Massoud, et al. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11030-5.
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