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BNZ132-1

Chemical Structure : BNZ132-1

CAS No.:

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BNZ132-1 (QITISILSQINRVFHEKFI)

Catalog No.: PC-38316Not For Human Use, Lab Use Only.

BNZ132-1 (QITISILSQINRVFHEKFI) is a specific peptide inhibitor for the IL-2/IL-15 subfamily, directly binds to the γc molecule (CD132).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BNZ132-1 (QITISILSQINRVFHEKFI) is a specific peptide inhibitor for the IL-2/IL-15 subfamily, directly binds to the γc molecule (CD132); BNZ132-1 shows no inhibition on non-γc-cytokines. BNZ132-1 inhibits γc-cytokines using murine PT-18 cells, but not IL-4/7/21. BNZ132-1 inhibits IL-2 and -15 with IC50 of 50-500 nM in human cells (NK92 cell line and ex vivo human T cells).

    Physicochemical Properties

    M.Wt
    Formula
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    Chemical Name/SMILES

    Sequence: QITISILSQINRVFHEKFI

    References

    1. Toshie Nata, et al. J Biol Chem. 2015 Sep 11;290(37):22338-51.

    2. T Tiffany Wang, et al. Leukemia. 2019 May;33(5):1243-1255.

    3. Raya Massoud, et al. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11030-5.

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