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Chemical Structure : BO-264
CAS No.: 2408648-20-2
Catalog No.: PC-38168Not For Human Use, Lab Use Only.
BO-264 (BO264) is a highly potent inhibitor of transforming acidic coiled-coil (TACC) family member TACC3 (IC50=188 nM).
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| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
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BO-264 (BO264) is a highly potent inhibitor of transforming acidic coiled-coil (TACC) family member TACC3 (IC50=188 nM).
The interaction between TACC3 and BO-264 with a dissociation constant, KD of 1.5 nM.
BO-264 inhibits the viability of cancer cells with FGFR3–TACC3 fusion and shows very potent cytotoxicity in NCI-60 cancer cell line panel.
TACC3 inhibition with BO-264 induces mitotic arrest, apoptosis, and DNA damage, causes aberrant spindle formation, and reduces centrosomal localization of TACC3.
BO-264 significantly impairs tumor growth and improves survival in in vivo xenograft and syngeneic models without major toxicity.
| M.Wt | 353.382 | |
| Formula | C18H19N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(4-methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine |
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1. Ozge Akbulut, et al. Mol Cancer Ther. 2020 Jun;19(6):1243-1254.
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