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Chemical Structure : BOC-D-FMK
CAS No.: 634911-80-1
Catalog No.: PC-43410Not For Human Use, Lab Use Only.
BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-α with IC50 of 39 uM.
BOC-D-FMK inhibits TNFα-stimulated reactive oxygen species (ROS) generation, prevents genistein-induced apoptosis of p815 cells at 50 uM.
BOC-D-FMK shows neuroprotective effects on spinal motoneurons (MNs) after root avulsion in neonatal rats, suppresses polyethylene particle-induced osteolysis in mice.
| M.Wt | 263.2627 | |
| Formula | C11H18FNO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 125 mg/mL |
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| Chemical Name/SMILES |
Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester |
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1. Cowburn AS, et al. Blood. 2005 Apr 1;105(7):2970-2.
2. Yee SB, et al. Exp Mol Med. 2006 Dec 31;38(6):634-42.
3. Chan YM, et al. Exp Neurol. 2003 Jun;181(2):190-203.
4. Landgraeber S, et al. Apoptosis. 2009 Feb;14(2):173-81.
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