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Chemical Structure : BOS-318
CAS No.: 2387633-15-8
Catalog No.: PC-72839Not For Human Use, Lab Use Only.
BOS-318 (BOS318) is a potent, highly selective, cell-permeable furin inhibitor with IC50 of 1.9 nM, Ki of 0.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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BOS-318 (BOS318) is a potent, highly selective, cell-permeable furin inhibitor with IC50 of 1.9 nM, Ki of 0.4 nM.
BOS-318 displays 13 times more potent against furin than PCSK5 (IC50 =25.3 nM), 24 times more potent than PCSK7 (IC50 =45.8 nM), and 110 times more potent than PCSK6 (IC50 =209.4 nM).
BOS-318 reduces endogenous proteases in the Golgi compartment in U2OS cells with IC50 of 23.5 nM.
BOS-318 provides protection against PEA-mediated cytotoxicity in a dose-dependent manner in CuFi-1 cells, over a period of 72 h, with an EC50 of 47.8 nM.
BOS-318 reduces ENaC-mediated Na+ absorption in CF HBECs after short- (2-h) and long-term (48-h) treatment and protects against NE- and CF sputum-sol-mediated activation of the ENaC.
| M.Wt | 571.503 | |
| Formula | C28H32Cl2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(1-((2-(3,5-dichlorophenyl)-6-((2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)oxy)pyridin-4-yl)methyl)piperidin-4-yl)acetic acid |
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1. Lisa E J Douglas, et al. Cell Chem Biol. 2022 Feb 22;S2451-9456(22)00052-6.
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