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Chemical Structure : BPA-B9
Catalog No.: PC-20840Not For Human Use, Lab Use Only.
BPA-B9 (Bipyridine amide B9) is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=39 nM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.
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BPA-B9 (Bipyridine amide B9) is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=39 nM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.
BPA-B9 showed better activity than XS-060, with excellent RXRα-binding affinity and anti-proliferative activity against MDA-MB-231 (IC50=16 nM).
BPA-B9 displayed better pharmacokinetics than the lead XS-060.
BPA-B9 had significant anticancer efficacy in vivo with no considerable side effects.
| M.Wt | 414.51 | |
| Formula | C25H26N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jun Chen, et al. Eur J Med Chem. 2023 Jun 5;254:115341.
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