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Chemical Structure : BPI-16350
Catalog No.: PC-23058Not For Human Use, Lab Use Only.
BPI-16350 (Tibremciclib) is a highly potent, selective CDK4/6 inhibitor with IC50 of 2.21 nM and 0.4 nM for CDK4/cyclinD1 and CDK6/cyclinD1, with less inhibition of CDK9 (IC50=91.6 nM).
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BPI-16350 (Tibremciclib) is a highly potent, selective CDK4/6 inhibitor with IC50 of 2.21 nM and 0.4 nM for CDK4/cyclinD1 and CDK6/cyclinD1, with less inhibition of CDK9 (IC50=91.6 nM).
BPI-16350 is far less active against other CDKs, such as CDK1/cyclinB, CDK2/cyclinE, CDK5/p25, and CDK7/cyclinH complexes.
BPI-16350 inhibits cell proliferation and viability by arresting cells at G1 phase.
BPI-16350 inhibited tumor growth by 71.7%, 89.5%, and 98.5% at dosages of 37.5, 75, and 150 mg/kg, respectively, in COLO 205 xenografts.
| M.Wt | 518.62 | |
| Formula | C28H32F2N8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jian Zhang, et al. 2023 ASCO Annual Meeting I
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