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BPK-29

Chemical Structure : BPK-29

CAS No.: 2143467-62-1

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BPK-29 (BPK29)

Catalog No.: PC-60016Not For Human Use, Lab Use Only.

BPK-29 (BPK29) is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BPK-29 (BPK29) is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
BPK-29 substantially engages NR0B1 (EC50<5 uM) with good overall proteomic selectivity in KEAP1-mutant NSCLCs.
BPK-29 target a conserved cysteine C274 within the NR0B1.

Physicochemical Properties

M.Wt 470.01
Formula C26H32ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-benzyl-2-chloro-N-(1-(4-morpholinobenzoyl)azepan-4-yl)acetamide

References

1. Bar-Peled L, et al. Cell. 2017 Oct 19;171(3):696-709.e23.

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