Chemical Structure : BPRCX714
CAS No.:
1892574-13-8
BPRCX714
(BPRCX 714)
Catalog No.: PC-49201Not For Human Use, Lab Use Only.
BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BPRCX714 (BPRCX 714) is a highly selective and potent CXCR4 antagonist with binding IC50 of 34.2 nM, effectively inhibits CXCL12-induced movement of CCRF-CEM cells with EC50 of 13.7 nM.
BPRCX714 exhibits no cross-activity against a panel of chemokine receptors in both CCR and CXCR types.
BPRCX714 is a promising drug candidate for PBSCT and other disease indications, can mobilize out neutrophils, lymphocytes and monocytes.
Physicochemical Properties
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M.Wt
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613.812
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Formula
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C30H51N11O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3-(4-((2-(((1-(3-((3-(cyclohexylamino)propyl)amino)propyl)-1H-1,2,3-triazol-4-yl)methyl)amino)-6-methylpyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropyl)glycine
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References
1. Chien-Huang Wu, et al. J Med Chem. 2018 Feb 8;61(3):818-833.
2. Jen-Shin Song, et al. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2015433118.
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