Catalog No.: PC-26024Not For Human Use, Lab Use Only.
BPU17 is a specific small molecule inhibitor of prohibitin, binds to prohibitin 1 (PHB1) and inhibits the PHB1-PHB2 interaction, inhibits epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) and exhibits antifibrotic activity in vivo.
BPU17 is a specific small molecule inhibitor of prohibitin, binds to prohibitin 1 (PHB1) and inhibits the PHB1-PHB2 interaction, inhibits epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs) and exhibits antifibrotic activity in vivo. BPU17 specifically binds to PHB1, but not PHB2, inhibits PHB1-PHB2 heterodimer. BPU17 inhibits phenotypic transition of TGF-β2-stimulated RPEs. BPU17 suppresses inflammatory stress-induced subretinal fibrosis in mouse model of retinal degeneration.
