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BR102910

Chemical Structure : BR102910

CAS No.: 2505339-54-6

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BR102910 (BR 102910)

Catalog No.: PC-72074Not For Human Use, Lab Use Only.

BR102910 (BR 102910) is a novel potent, selective, oral fibroblast activation protein (FAP) inhibitor with IC50 of 1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BR102910 (BR 102910) is a novel potent, selective, oral fibroblast activation protein (FAP) inhibitor with IC50 of 1 nM.
BR102910 displays high selectivity over DPPIV and prolyl oligopeptidase (PREP).
BR102910 demonstrated exceptional profiles and satisfactory FAP inhibition efficacy in vivo FAP inhibition study using C57BL/6J mice.

Physicochemical Properties

M.Wt 459.293
Formula C18H14Cl2F2N4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)-2-(3,4-dichlorobenzyl)thiazole-4-carboxamide

References

1. Hui Jin Jung, et al. Bioorg Med Chem Lett. 2021 Apr 1;37:127846.

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