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BRD-7880

Chemical Structure : BRD-7880

CAS No.: 1456542-69-0

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BRD-7880 (BRD 7880;BRD7880)

Catalog No.: PC-61195Not For Human Use, Lab Use Only.

BRD-7880 (BRD7880) potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD-7880 (BRD7880) potent and highly specific inhibitor of Aurora B and Aurora C with IC50 of 7 and 12 nM respectively, with less activity against Aurora A (IC50>2 uM).
    BRD-7880 is far more selective than tozasertib (VX-680), substantially inhibiting (to < 25% control activity) only AURKB and AURKC in a panel of 308 kinases.

    Physicochemical Properties

    M.Wt 590.677
    Formula C32H38N4O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((2R,3S)-2-(((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)methyl)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-8-yl)-3-(4-methoxyphenyl)urea

    References

    1. Yu C, et al. Nat Biotechnol. 2016 Apr;34(4):419-23.

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