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Chemical Structure : BRD1732
Catalog No.: PC-21989Not For Human Use, Lab Use Only.
BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system.
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BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system.
Ubiquitination of BRD1732 and its associated cytotoxicity are stereospecific and dependent upon two homologous E3 ubiquitin ligases, RNF19A and RNF19B.
| M.Wt | 404.49 | |
| Formula | C25H25FN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li W, et al. bioRxiv [Preprint]. 2024 Jan 28:2024.01.26.577493.
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