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BRD1732

Chemical Structure : BRD1732

CAS No.:

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BRD1732 (BRD 1732)

Catalog No.: PC-21989Not For Human Use, Lab Use Only.

BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD1732 is an ubiquitinated bifunctional small molecule that could be directly ubiquitinated in cells, resulting in dramatic accumulation of inactive ubiquitin monomers and polyubiquitin chains causing broad inhibition of the ubiquitin-proteasome system.
    Ubiquitination of BRD1732 and its associated cytotoxicity are stereospecific and dependent upon two homologous E3 ubiquitin ligases, RNF19A and RNF19B.

    Physicochemical Properties

    M.Wt 404.49
    Formula C25H25FN2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(((2S,3R,4R)-3-([1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidin-2-yl)methyl)-3-fluoro-N-methylbenzamide

    References

    1. Li W, et al. bioRxiv [Preprint]. 2024 Jan 28:2024.01.26.577493.

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