BRD4 inhibitor Compound V

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Chemical Structure : BRD4 inhibitor Compound V

Catalog No.: PC-35692Not For Human Use, Lab Use Only.

BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.
BRD4 inhibitor Compound V demonstrates reduction of c-Myc expression, inhibition of NF-κB signaling, and suppression of IL-8 production through potential synergistic inhibition of BRD4(1) and p38α.

Physicochemical Properties

M.Wt	442.542
Formula	C26H27FN6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-dimethylphenyl)-4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1Himidazol-5-yl)pyrimidin-2-amine

References

1. Anand Divakaran, et al. J. Med. Chem., 2018, 61 (20), pp 9316-9334.

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