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BRD4 inhibitor Compound V

Chemical Structure : BRD4 inhibitor Compound V

CAS No.: 2259638-53-2

BRD4 inhibitor Compound V

Catalog No.: PC-35692Not For Human Use, Lab Use Only.

BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.
    BRD4 inhibitor Compound V demonstrates reduction of c-Myc expression, inhibition of NF-κB signaling, and suppression of IL-8 production through potential synergistic inhibition of BRD4(1) and p38α.

    Physicochemical Properties

    M.Wt 442.542
    Formula C26H27FN6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(3,5-dimethylphenyl)-4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1Himidazol-5-yl)pyrimidin-2-amine

    References

    1. Anand Divakaran, et al. J. Med. Chem., 2018, 61 (20), pp 9316-9334.

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