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BRD50837

Chemical Structure : BRD50837

CAS No.: 1314295-24-3

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BRD50837 (BRD 50837)

Catalog No.: PC-62851Not For Human Use, Lab Use Only.

BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM, partially lowers Gli1 expression at concentrations of 2 uM, a useful probe of Shh signaling pathway. .

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD50837 is a potent, selective, small-molecule inhibitor of the Sonic Hedgehog (Shh) pathway with EC50 of 90 nM, partially lowers Gli1 expression at concentrations of 2 uM, a useful probe of Shh signaling pathway.

    Physicochemical Properties

    M.Wt 550.067
    Formula C26H32ClN3O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((2R,3S)-2-(((4-chloro-N-methylphenyl)sulfonamido)methyl)-5-((R)-1-hydroxypropan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-10-yl)cyclopropanecarboxamide

    References

    1. Schaefer GI, et al. J Am Chem Soc. 2013 Jul 3;135(26):9675-80.

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