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BRD8 inhibitor DN01

Chemical Structure : BRD8 inhibitor DN01

CAS No.: 2965690-32-6

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BRD8 inhibitor DN01

Catalog No.: PC-38761Not For Human Use, Lab Use Only.

BRD8 inhibitor DN01 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 12 nM, displays IC50 of 0.21 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD8 inhibitor DN01 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 12 nM, displays IC50 of 0.21 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300.

    Physicochemical Properties

    M.Wt 370.424
    Formula C21H23FN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-((dimethylamino)methyl)-2,6-dimethoxyphenyl)-7-fluoro-2-methylisoquinolin-1(2H)-one

    References

    1. David Remillard, et al. ACS Chem Biol. 2021 Nov 19;16(11):2185-2192.

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