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BRM011

Chemical Structure : BRM011

CAS No.: 2270875-79-9

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BRM011 (dual BRM and BRG1 inhibitor 11)

Catalog No.: PC-72942Not For Human Use, Lab Use Only.

BRM011 (dual BRM and BRG1 inhibitor 11) is a potent, selective, allosteric dual BRM and BRG1 inhibitor with IC50 of <5 nM for both.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BRM011 (dual BRM and BRG1 inhibitor 11) is a potent, selective, allosteric dual BRM and BRG1 inhibitor with IC50 of <5 nM for both.
BRM011 inhibits proliferation in BRG1-mutant SKMEL5 cells with IC50 of 13 nM.
BRM011 demonstrated a profound sensitivity across growth inhibition across 100 cancer cell lines from various cancer primary sites.
BRM011 phenocopies effects of dual knockdown of BRG1 and BRM, decreases MYC gene expression, induces apoptosis and differentiation across hematopoietic cancer cell lines.

Physicochemical Properties

M.Wt 319.715
Formula C10H8ClF2N5OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
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Solubility

Chemical Name/SMILES

References

1. Papillon JPN, et al. J Med Chem. 2018 Nov 21;61(22):10155-10172.

2. Rago F, et al. Mol Cancer Res. 2022 Mar 1;20(3):361-372.

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