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Chemical Structure : BRM014
CAS No.: 2270879-17-7
Catalog No.: PC-35746Not For Human Use, Lab Use Only.
BRM014 (BRM-014) is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $388 | In stock | |
| 5 mg | $588 | In stock | |
| 10 mg | $958 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BRM014 (BRM-014) is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both.
BRM014 modulates SWI/SNF chromatin-remodeling activity via inhibition of the ATPase activity.
BRM014 downregulates BRM-dependent gene expression and shows antiproliferative activity in a BRG1-mutant-lung-tumor xenograft model.
| M.Wt | 318.274 | |
| Formula | C11H9F3N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea |
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1. Papillon JPN, et al. J Med Chem. 2018 Oct 31. doi: 10.1021/acs.jmedchem.8b01318.
2. Rago F, et al. Mol Cancer Res. 2022 Mar 1;20(3):361-372.
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