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BTT-877

Chemical Structure : BTT-877

CAS No.: 2156655-68-2

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BTT-877 (BTT877)

Catalog No.: PC-49584Not For Human Use, Lab Use Only.

BTT-877 (BTT877) is a potent, selective and orally active inhibitor of autotaxin (ENPP2) with in vitro and ex vivo IC50 of 2.4 nM and 6.89 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BTT-877 (BTT877) is a potent, selective and orally active inhibitor of autotaxin (ENPP2) with in vitro and ex vivo IC50 of 2.4 nM and 6.89 nM, respectively.
    BTT-877 potently inhibits LPA-induced cell migtation, suppresses inflammation and sclerosis by reducing LPA production through the selective inhibition of autotaxin.
    BTT-877 demonstrated in vivo anti-fibrotic efficacy in the mouse model of bleomycin-induced pulmonary fibrosis.

    Physicochemical Properties

    M.Wt 443.47
    Formula C22H21N9O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[5-[2-[(2,3-Dihydro-1H-inden-2-yl)amino]-5-pyrimidinyl]-1,3,4-oxadiazol-2-yl]-1-(3,4,6,7-tetrahydro-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl)ethanone

    References

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