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BTYNB

Chemical Structure : BTYNB

CAS No.: 304456-62-0

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BTYNB (IMP1 inhibitor BTYNB)

Catalog No.: PC-61770Not For Human Use, Lab Use Only.

BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $368 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM.
BTYNB has no effect on binding of PR to flPRE.
BTYNB destabilizes c-Myc mRNA, downregulates β-TrCP1 mRNA and reduces activation of NF-κB.
BTYNB also decreases oncogenic translation regulator eEF2 mRNA levels in cancer cells.
BTYNB potently inhibits proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells.

Physicochemical Properties

M.Wt 309.181
Formula C12H9BrN2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-(((5-bromothiophen-2-yl)methylene)amino)benzamide

References

1. Mahapatra L, et al. Transl Oncol. 2017 Oct;10(5):818-827.

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