Catalog No.: PC-35107Not For Human Use, Lab Use Only.
BTZO-1 is a cardioprotective agent and Macrophage migration inhibitory factor (MIF) activator, binds to MIF with Kd of 68.6 nM, regulates ARE-mediated gene expression.
BTZO-1 is a cardioprotective agent and Macrophage migration inhibitory factor (MIF) activator, binds to MIF with Kd of 68.6 nM, regulates ARE-mediated gene expression.
BTZO-1 activates the GST Ya gene ARE by interacting with MIF.
BTZO-1 induced expression of cytoprotective proteins such as heme oxygenase-1 (HO-1) and suppressed oxidative stress-induced cardiomyocyte apoptosis via binding to macrophage migration inhibitory factor (MIF).
Physicochemical Properties
M.Wt
240.28
Formula
C13H8N2OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
References
1. Kimura H, et al. Chem Biol. 2010 Dec 22;17(12):1282-94.
