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BTZO-15

Chemical Structure : BTZO-15

CAS No.: 916799-65-0

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BTZO-15 (BTZO15)

Catalog No.: PC-35109Not For Human Use, Lab Use Only.

BTZO-15 is an active BTZO-1 derivative for ARE-activation with a favorable ADME-Tox profile, induces expression of heme oxygenase-1 (HO-1) and inhibits NO-induced cell death in IEC-18 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BTZO-15 is an active BTZO-1 derivative for ARE-activation with a favorable ADME-Tox profile, induces expression of heme oxygenase-1 (HO-1) and inhibits NO-induced cell death in IEC-18 cells.
    BTZO-15 induces HO-1 expression in the rectum and attenuates DSS-induced changes, reduces the ulcerated area and rectal MPO activity in TNBS-induced colitis rats without affecting rectal TNF-α levels; orally active.

    Physicochemical Properties

    M.Wt 424.87
    Formula C17H13ClN2O5S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-[6-(7-chloro4-oxo-4H-1,3-benzothiazin-2-yl)-4-(methylsulfonyl)pyridin-2-yl]propanoic acid

    References

    1. Yukitake H, et al. PLoS One. 2011;6(8):e23256.

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