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BX-320

Chemical Structure : BX-320

CAS No.: 702676-93-5

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BX-320 (BX320)

Catalog No.: PC-63030Not For Human Use, Lab Use Only.

BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM, >20-fold selectivity over PKA.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM, >20-fold selectivity over PKA.
    BX-320 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis.
    BX-320 inhibits the growth of LOX melanoma tumors in the lungs of nude mice.

    Physicochemical Properties

    M.Wt 547.458
    Formula C23H31BrN8O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Propanediamide, N-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2-dimethyl- (9CI)

    References

    1. Feldman RI, et al. J Biol Chem. 2005 May 20;280(20):19867-74.

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