| Cat. No. |
Product Name |
Information |
| PC-49261 |
GSK2334470
PDK1 inhibitor
|
GSK2334470 (GSK 2334470) is a potent, highly specific inhibitor of PDK1 with IC50 of 10 nM, does not inhibit 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 5 uM. |
| PC-73258 |
PDK1 agonist PS48
PDK1 agonist
|
PDK1 agonist PS48 is a small molecule allosteric phosphoinositide-dependent protein kinase-1 (PDK-1) agonist, PS48 is active at 10 nM to 1 μM in restoring normal insulin-dependent Akt activation and in mitigating Aβi peptide toxicity. |
| PC-63030 |
BX-320
PDK1 inhibitor
|
BX-320 is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 30 nM, >20-fold selectivity over PKA. |
| PC-62481 |
PS210
PDK1 actvivator
|
PS210 is a potent, specific activator of PDK1 that target the PIF-binding pocket of PDK1, does not alter the activity of any of the 121 kinases (S6K, PKB/Akt or GSK3). |
| PC-62480 |
PS423
PDK1 inhibitor
|
PS 423 is a substrate-selective inhibitor of PDK1, inhibits the phosphorylation and activation of S6K without affecting the PKB/Akt signaling pathway in HEK293 cells, the prodrug of PS210. |
| PC-61111 |
PDK1 inhibitor 7
PDK1 inhibitor
|
PDK1 inhibitor 7 (MP7) is a potent, selective PDK1 inhibitor with IC50 of 1 nM, displays >3,000-fold selectivity against a panel of 256 kinases. |
| PC-60606 |
OSU-03013
PDK1 inhibitor
|
OSU-03013 (OSU 03013, OSU03013) is a potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) inhibitor with IC50 of 2 uM. |
| PC-60605 |
PDK1 inhibitor AR12
PDK1 inhibitor
|
OSU-03012 (AR12) is a potent, orally active 3-phosphoinositide-dependent kinase-1 (PDK-1) inhibitor with IC50 of 5 uM. |
| PC-42781 |
BX-912
PDK1 inhibitor
|
BX-912 (BX912) is a potent, selective and ATP-competitive inhibitor of PDK1 with IC50 of 26 nM. |
| PC-42629 |
BX795
PDK1 inhibitor, TBK1 inhibitor
|
BX795 is a potent and relatively specific PDK1 inhibitor with IC50 of 6 nM. |
| PC-21484 |
CU05-1189
PDK1 inhibitor
|
CU05-1189 is a non-peptide, allosteric inhibitor of the pleckstrin homology (PH) domain of PDK1, specifically inhibits Akt signaling pathway. |
